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Alford Lab

PUBLICATIONS

[27] Steucke KE, Win Z, Stemler TR, Walsh EE, Hall JL, Alford PW (2017) Empirically determined vascular smooth muscle cell mechano-adaptation law. J Biomech Eng, in press. PMID28418526

[26] Win Z, Buksa JM, Steucke KE, Luxton GWG, Barocas VH, Alford PW (2017) Cellular microbiaxial stretching to measure a single-cell strain energy density function. J Biomech Eng, in press. PMID28397957

[25] Ray A, Lee O, Win Z, Edwards RM, Alford PW, Provenzano PP (2017) Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration. Nat Commun, 8:14923. PMID28401884

[24] Witzenburg CM, Dhume RY, Shah SB, Korenczuk CE, Wagner HP, Alford PW, Barocas VH (2017) Failure of the porcine ascending aorta: multidirectional experiments and a unifying microstructural model. J Biomech Eng, 139(3):1-14. PMID27893044

[23] Hald ES, Timm CD, Alford PW (2016) Amyloid beta influences vascular smooth muscle contractility and mechanoadaptation. J Biomech Eng, 138(11). PMID27590124

[22] van Loosdregt IA, Dekker S, Alford PW, Oomens CW, Loerakker S, Bouten CV (2016) Intrinsic cell stress is indepedent of organization in engineered cell sheets. Cardiovasc Eng Technol, 1-12. PMID2778297

[21] Steucke KE, Tracy PV, Hald ES, Hall JL, Alford PW (2015) Vascular smooth muscle cell functional contractility depends on extracellular mechanical properties. J Biomech, 48(12):3044-51. PMID26283412

[20] Lee H, Adams WJ, Alford PW, McCain ML, Feinberg AW, Sheehy SP, Goss JA, Parker KK (2015) Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes. Exp Biol Med. 240(11):1543-54.PMID25908635

[19] Alford PW (2015) Elasticity-based targeted growth models of morphogenesis. Methods in Molecular Biology, 1189:339-50. PMID25245704

[18] Adhikari N, Shekar KC, Staggs R, Win Z, Steucke KE, Lin Y, Wei L, Alford PW, Hall JL (2015) Guidelines for the isolation, culturing, and characterization of murine vascular smooth muscle cells. J cardiovasc Transl Res, 8(3):158-63. PMID25788147

[17] Hald ES, Steucke KE, Reeves J, Win Z, Alford PW (2014) Microfluidic genipin deposition technique for extended culture of micropatterned vascular muscular thin films. JOVE, (100)e52971. PMID26168271

[16] Win Z, Vrla GD, Steucke KE, Sevcik EN, Hald ES, Alford PW (2014) Smooth muscle architecture within cell-dense vascular tissue influence functional contractility. Integr Biol, 6: 1201-1210. PMID25363686

[15] Hald ES, Steucke KE, Reeves J, Win Z, Alford PW (2014) Long-term vascular contractility assay using genipin-modified muscular thin films. Biofabrication, 6(4):045005. PMID25245868

[14] Shah S, Witzenburg C, Hadi MF, Wagner H, Goodrich J, Alford P, Barocas VH (2014) Prefailure and Failure Mechanics of the Porcine Ascending Thoracic Aorta: Experiments in a Multiscale Model. J Biomech Eng, 136(2), 21-28. PMID24402447

[13] Hald ES, Alford PW (2014) Smooth Muscle Phenotype Switching in Blast Traumatic Brain Injury-Induced Cerebral Vasospasm. Trans Stroke Res, 108(31), 12705-10. PMID24323722

[12] Ye GJC, Aratyn-Schaus Y, Nesmith AP, Pasqualini FS, Alford PW, Parker KK (2014) The contractile strength of vascular smooth muscle myocytes is shape dependent . Integr Biol, 6: 152-156. PMID24406783

[11] Feinberg AW, Alford PW, Jin H, Ripplinger CM, Sheehy SP, Werdich A, Parker KK (2012) Contolling the Contractile Strength of Engineered Cardiac Muscle by Hierarchal Tissue Architecture Biomaterials, 33(23), 5732-5741. PMID22594976

[10] Grosberg A, Alford PW, McCain ML, Parker KK (2011) Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip. Lab Chip, 11(24): 4165-73. PMID22072288

[9] Balachandran KB, Alford PW, Wylie-Sears J, Goss JA, Grosberg A, Bischoff J, Aikawa E, Levine R, Parker KK (2011) Cyclic Strain Induces Dual-Mode Endothelial-Mesenchymal Transformation of the Cardiac Valve. Proc Natl Acad Sci USA, 108(50): 19943-19948. PMID22123981

[8] Alford PW, Nesmith AP, Seywerd JN, Grosberg A, Parker KK (2011) Smooth Muscle Contractility Depends on Cell Shape. Integr Biol, 3(11): 1063-1070. PMID21993765 Featured cover article.

[7] Alford PW, Dabiri BE, Goss JA, Brigham MD, Hemphill MA, Parker KK (2011) Blast-Induced Phenotypic Switching in Cerebral Vasospasm. Proc Nat Acad Sci, 108(31): 12705-12710. PMID21765001 Highlighted in Nature. 28 July 2011.

[6] Hemphill MA, Dabiri BE, Gabriele S, Kerscher L, Franck C, Goss JA, Alford PW, Parker KK (2011) A Possible Role for Integrin Signaling in Diffuse Axonal Injury. PLoS One, 6:e22899.PMID21799943 Highlighted in Nature. 28 July 2011.

[5] Alford PW, Feinberg AW, Sheehy SP, Parker KK (2010) Biohybrid Thin Films for Measuring Contractility in Engineered Cardiovascular Muscle. Biomaterials, 31: 3613-3621. PMID20149449

[4] Alford PW, Taber LA (2008) Computational study of growth and remodelling in the aortic arch. Comput Methods Biomech Biomed Engin, 11: 525-38. PMID18792831

[3] Alford PW, Humphrey JD, Taber LA (2008) Growth and remodeling in a thick-walled artery model: effects of spatial variations in wall constituents. Biomech Model Mechanobiol, 7: 245-62. PMID2594015

[2] Voronov DA, Alford PW, Xu G, Taber LA (2004) The role of mechanical forces in dextral rotation during cardiac looping in the chick embryo. Dev Biol, 272(2): 339-50. PMID15282152

[1] Alford PW, Taber LA (2004) Regional epicardial strain in the embryonic chick heart during the early looping stages. J Biomech, 36(8): 1135-41. PMID12831739


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